- Lewis R. Gibbes Papers, 1800s-1893, 193712
- 1920s Charleston Scenes4
- 1938 Tornado Photograph Collection37
- 1967 King Street Survey Collection25
- 2nd South Carolina Regiment Order Book and Related Records, 1777-ca. 19291
- 2nd South Carolina Regiment Paybook, 17751
- 2nd South Carolina Regiment Records, 1778-17791
- 72/74 Tradd Street Ownership History Scrapbook1
- Account Books of Benjamin Perry's Wards, 1841-18642
- Accounts and Estate Administration Books, 1824-18525
- Adger Family Papers, 1813-193211
- Advertisement for Madame Togno's School for Young Ladies, ca. 18551
- After the Great Quake: Earthquake Views1
- Agatha Aimar Simmons Papers, 1903-19621
- Agricultural Experiments and South Mulberry Plantation Journal, 1841-1907 (bulk 1841-1867)1
- Agricultural Society of South Carolina Visual Materials211
- Albert Simons Papers, 1908-19774
- Albert Sottile, Jr. Papers250
- Ale boycott records, 18904
- Alexander Glennie Journal, 1831-18591