- Adger Family Papers, 1813-19323
- Buildings and Properties, 1841-19373
- Drayton Papers, 1701-20043
- Kahal Kadosh Beth Elohim Congregation Records3
- Accounts and Estate Administration Books, 1824-18522
- Charleston Slave Passes2
- Friendly Moralist Society Records, 1841-18562
- Historical and Governing Records, 1841-19252
- Nathaniel Russell House Museum Collection2
- Reverend Alexander Glennie Meteorological Observations, 1834-18802
- Woodward Manning Papers, 1771-19062
- College of Charleston Board of Trustees Minutes1
- College of Charleston Pamphlet Collection1
- Cora Godfrey Justice Family Papers, 1816-19871
- Deas Family Papers and Research, 1766-19761
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)1
- Hasell Family Papers, 1803 - 18841
- Illustrated Newspaper Clippings, 1840-19171
- J. F. R. Papers, 1849-18551
- James N. Cochran Papers, 1838-18871