- Barnwell Family Papers626
- Jack Keilen Slide Collection593
- Joseph A. Towles Artifact Collection552
- Phosphate, Farms, & Family: The Donner Collection548
- Lynch Family Letters, 1858-1866447
- Heyward and Ferguson Family Papers, 1806-1923389
- J. Arthur Brown Papers, 1937 - 1988380
- Russell J. Arnsberger Postcard Collection359
- Bettie La Barbe Postcard Collection327
- George W. Johnson Photographs322
- Edmondston-Alston Family Letters and Paper Materials, 1782-1919309
- Anna D. Kelly Papers, 1930s - 1999307
- Henry Laurens papers, 1747-1860301
- The Lucille Hasell Culp Collection300
- Charleston Museum Illustrated Newspapers Collection292
- Jewish Heritage Collection Oral Histories284
- Senator Burnet R. Maybank Papers, 1914-1973283
- Susan Pringle Alston’s Receipts, 1891-1921278
- Mamie E. Garvin Fields Papers, 1894 - 1987271
- Avery Normal Institute263