- Ball Family Papers, 1631-1895450
- Langdon Cheves Papers, 1777-186441
- Allston Family Papers, 1730-190137
- William A. Rosenthall Judaica Collection - Postcards18
- Cranston Family Papers, 1822-195915
- Woodward Manning Papers, 1771-19069
- Rabbi Jacob S. Raisin Papers8
- Henry Laurens papers, 1747-18606
- Thomas J. Tobias papers, ca. 1790-19705
- American Revolution Records in the Discrete Manuscript Collection2
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2
- Ragsdale Family Papers, 1844-ca.19202
- Robert Heriot Correspondence, 17812
- Transactions of the Huguenot Society of South Carolina2
- William Moultrie Correspondence, 17812
- Charleston Bible Society Records, 1815-20101
- Cohen, Emanuel, Moses, Seixas Family Papers1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)1
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Drayton Family Papers, 1837-18691