- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-199596
- Septima P. Clark Papers, ca. 1910-ca. 199046
- J. Arthur Brown Papers, 1937 - 198837
- Cleveland L. Sellers, Jr. Papers, 1934 - 200322
- William ("Bill") Saunders Papers, circa 1950 - 200421
- Bernice Robinson Papers, 1920-198910
- Mamie E. Garvin Fields Papers, 1894 - 19878
- Esau Jenkins Papers, 1963-20035
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)4
- Edmondston-Alston Family Letters and Paper Materials, 1782-19193
- Eugene C. Hunt Papers, 1834 - 19943
- L.A. Hall Civil War and Reconstruction Eras Stereoscopic Images3
- Postcard Collection of Mullins, South Carolina3
- Rabbi Jacob S. Raisin Papers2
- Agricultural Society of South Carolina Visual Materials1
- Cohen, Emanuel, Moses, Seixas Family Papers1
- Drayton Family Papers, 1837-18691
- Ethelyn Murray Parker Papers1
- Grimke family papers, 1678-19771
- Harry Blas and Erika Stockfleth Blas Papers, circa 1910-circa 19801