- Civic Services Committee Papers1,139
- Ball Family Papers, 1631-1895791
- Gertrude Sanford Legendre Papers, 1844-1996664
- Barnwell Family Papers622
- Lynch Family Letters, 1858-1866447
- Heyward and Ferguson Family Papers, 1806-1923389
- Henry Laurens papers, 1747-1860295
- Allston Family Papers, 1730-1901247
- Wilkinson-Keith Family Papers241
- Edmondston-Alston Family Letters and Paper Materials, 1782-1919222
- Grimke family papers, 1678-1977199
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995190
- YWCA of Greater Charleston, Inc., Records, 1906 - 2007151
- Langdon Cheves Papers, 1777-1864142
- William ("Bill") Saunders Papers, circa 1950 - 2004124
- St. Andrew's Society of Charleston Records, 1729-2001118
- Bernice Robinson Papers, 1920-1989111
- Rabbi Jacob S. Raisin Papers109
- Pierrine Smith Byrd Papers, 1919-1991102
- Septima P. Clark Papers, ca. 1910-ca. 199098