- Edmondston-Alston Family Letters and Paper Materials, 1782-191912
- J. Arthur Brown Papers, 1937 - 198810
- Records of Charleston fire companies, 1862-18647
- Isaac Harby Family Papers6
- Lazarus and Hirsch Family Papers6
- Anita Pollitzer Family Papers5
- Laura Bragg Papers5
- Ale boycott records, 18904
- Anna D. Kelly Papers, 1930s - 19994
- Phillis Wheatley Literary and Social Club Papers4
- Warren Hubert Moise Letters, 1933-19394
- American Federation of Musicians Local 502 records, 1911-19143
- Charleston Slave Passes3
- Esau Jenkins Papers, 1963-20033
- Sandy Island Plantation Journals/Almanacs, 1792-17983
- South Carolina Historical Society Manuscripts3
- Temple Sinai (Sumter, S.C.) Records3
- Charleston Iron Works records, 19072
- Craft and Crum Families, 1780-20072
- Eighteenth & Nineteenth Century Correspondence Collection2