- SCDOT Photographs: Properties in the Right-of-Way2,276
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613
- William A. Rosenthall Judaica Collection - Prints and Photographs1,584
- John Henry Dick Collection1,185
- College of Charleston Buildings and Grounds Photograph Collection1,059
- Photos from the Records of The Historic Preservation Planner, BCD-COG985
- City of Charleston Board of Architectural Review Photographs Collection913
- Charleston Naval Shipyard Photographs819
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)784
- Jack Keilen Slide Collection593
- Phosphate, Farms, & Family: The Donner Collection548
- Gertrude Sanford Legendre Papers, 1844-1996511
- YWCA of Greater Charleston, Inc., Records, 1906 - 2007443
- Bettie La Barbe Postcard Collection327
- George W. Johnson Photographs322
- The Lucille Hasell Culp Collection300
- Charleston Museum Illustrated Newspapers Collection292
- Septima P. Clark Papers, ca. 1910-ca. 1990257
- Anna D. Kelly Papers, 1930s - 1999254
- Ansonborough Rehabilitation Project Photograph Survey231