- Heyward and Ferguson Family Papers, 1806-19232
- Kahal Kadosh Beth Elohim Congregation Records2
- Slave Records in the Discrete Manuscript Collection2
- Agricultural Experiments and South Mulberry Plantation Journal, 1841-1907 (bulk 1841-1867)1
- Bacot Family Papers, 1752-19731
- Ball Family Papers, 1631-18951
- Cote Bas and Mepkin Plantations Journals, 1865-18771
- Gaillard Family Papers, 1758-19011
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- John C. Calhoun Letters, 1824-18501
- John McCrady Plats and Deeds Collection1
- Mathurin Guerin Gibbs Plantation Register, 1824-18751
- Middleton Family Papers, 1736-19291
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)1
- Pearlstine-Strauss Family Papers1
- Pinckney Family Papers, 1703-18471
- Ravenel Family Papers, 1695-19251
- Small-Whaley Family Papers, 1796-19941
- Thomas J. Tobias papers, ca. 1790-19701
- Vanderhorst Family Papers, 1689-19421