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Collection
- Lynch Family Letters, 1858-1866447
- Heyward and Ferguson Family Papers, 1806-1923276
- Barnwell Family Papers270
- Edmondston-Alston Family Letters and Paper Materials, 1782-1919122
- Wilkinson-Keith Family Papers119
- Allston Family Papers, 1730-190195
- Langdon Cheves Papers, 1777-186462
- Ball Family Papers, 1631-189549
- Flagg Family Papers, 1832-192647
- Drayton Family Papers, 1837-186938
- Thomas J. Tobias papers, ca. 1790-197038
- Slave Records in the Discrete Manuscript Collection33
- Walter Pantovic Slavery and African American History Collection28
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- Kahal Kadosh Beth Elohim Congregation Records24
- Grimke family papers, 1678-197722
- Historical and Governing Records, 1841-192518
- John R. Beaty Letters17
- Charleston Firefighters Rosters, 1862-186416
- Newton Plantation Collection16