- Bacot Family Papers, 1752-197315
- Edmondston-Alston Family Letters and Paper Materials, 1782-191915
- Ball Family Papers, 1631-189613
- Adger Family Papers, 1813-193211
- Drayton Papers, 1701-200411
- James Simons Papers, 1832-187911
- The Charleston Oral History Program11
- Ragsdale Family Papers, 1844-ca.192010
- Glover Family Papers, 1729-ca.19559
- Septima P. Clark Papers, ca. 1910-ca. 19909
- Esau Jenkins Papers, 1963-20038
- Ravenel Family Papers, 1695-19258
- Records of the Church of the Holy Cross, 1788-19428
- Summerville Museum and Research Center Pamphlet Collection8
- Eugene C. Hunt Papers, 1834 - 19947
- Ethelyn Murray Parker Papers6
- Accounts and Estate Administration Books, 1824-18525
- Coffin Point Plantation Journals, 1800-18165
- Gertrude Sanford Legendre Papers, 1844-19965
- Millicent E. Brown Papers, 1949 - 20035