- Drayton Papers, 1701-20042
- Letters to Jonathan Lucas, 17962
- Robert Heriot Correspondence, 17812
- Sandy Island Plantation Journals/Almanacs, 1792-17982
- South Carolina Historical Society Manuscripts2
- Wilkinson-Keith Family Papers2
- 2nd South Carolina Regiment Order Book and Related Records, 1777-ca. 19291
- Agricultural Society of South Carolina Visual Materials1
- Benjamin H. Rutledge Family Papers, 1675-18671
- Charles Fraser Sketchbook, 1793-17961
- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- College of Charleston Board of Trustees Minutes1
- Colleton County Memorial Library Map Collection1
- Eliza Pinckney Receipt Book1
- General Orders of William Moultrie and Benjamin Lincoln, 17791
- Henry Laurens Account Book, 1766-17331
- Invoice of rice sales for Anthony Clarkson, 1762 Oct. 301
- Isaac Hayne Journal: Register, ca. 1764-17811
- Joseph A. Towles Artifact Collection1
- Letter to Harriott Horry, ca. 17801