- Beaufort Hurricane of 1893 Photograph Collection20
- Benjamin H. Rutledge Family Papers, 1675-18671
- Bernice Robinson Papers, 1920-19891,131
- Berry Family Papers, 1767-19291
- Bettie La Barbe Postcard Collection327
- Book Lovers' Club, 1927 - 196940
- Bowman Family Papers, 1835-18924
- Buildings and Properties, 1841-193749
- Burton L. Padoll Papers, 1957-2009110
- Business Guide of Charleston, S.C.1
- Camp St. Mary Records, 1931-1997, undated3
- Carlton Simmons Collection2
- Catherine and James Yatsco Collection47
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Cross Collection of Buchenwald Concentration Camp Photographs, 194518
- Charles Fraser Book of Precedents, 1800-18191
- Charles Fraser Sketchbook, 1793-17961
- Charles Fraser's Sketchbook, 1796-1805115
- Charles Henry Meltzer Papers, 1839-194012
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613