- Mamie E. Garvin Fields Papers, 1894 - 1987129
- Photograph Survey of the “Charleston Center” Site110
- Pierrine Smith Byrd Papers, 1919-1991108
- Anna D. Kelly Papers, 1930s - 1999103
- Aqui Estamos99
- Charleston Naval Shipyard Photographs96
- Images from the Records of the Charleston County Public Library95
- Ansonborough Rehabilitation Project89
- Halley's Comet Project, 1985-198688
- Eugene C. Hunt Papers, 1834 - 199485
- Philip Simmons Collection83
- Isaiah Bennett Papers, ca. 1932-200270
- Burton L. Padoll Papers, 1957-200969
- Ethelyn Murray Parker Papers66
- McLeod Family Papers, 1873-1990 (bulk 1900-1965)64
- L. Mendel Rivers Papers, 1940-196263
- Avery Normal Institute50
- William A. Rosenthall Judaica Collection - Prints and Photographs48
- Catherine and James Yatsco Collection46
- Millicent E. Brown Papers, 1949 - 200343