- Alexander Inglis Papers, 1782-1811 (bulk 1800-1802)2
- Drayton Papers, 1701-20042
- Letters to Jonathan Lucas, 17962
- Robert Heriot Correspondence, 17812
- Sandy Island Plantation Journals/Almanacs, 1792-17982
- South Carolina Historical Society Manuscripts2
- Wilkinson-Keith Family Papers2
- William Moultrie Correspondence, 17812
- 2nd South Carolina Regiment Order Book and Related Records, 1777-ca. 19291
- 2nd South Carolina Regiment Paybook, 17751
- 2nd South Carolina Regiment Records, 1778-17791
- Agricultural Society of South Carolina Visual Materials1
- Benjamin H. Rutledge Family Papers, 1675-18671
- Charles Fraser Sketchbook, 1793-17961
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)1
- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- College of Charleston Board of Trustees Minutes1
- Colleton County Memorial Library Map Collection1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)1
- Eliza Pinckney Receipt Book1