- James E. Campbell papers, 1930-200995
- Walter Pantovic Slavery and African American History Collection93
- City of Charleston Board of Architectural Review Photographs Collection92
- Ball Family Papers, 1631-189586
- Wilkinson-Keith Family Papers82
- George W. Williams Photograph Collection74
- Joseph A. Towles Artifact Collection73
- Barnwell Family Papers72
- John McCrady Plats and Deeds Collection55
- J. Arthur Brown Papers, 1937 - 198853
- Philip Simmons Collection53
- Esau Jenkins Papers, 1963-200349
- Avery Normal Institute46
- Postcard Collection of Mullins, South Carolina44
- William ("Bill") Saunders Papers, circa 1950 - 200442
- Burton L. Padoll Papers, 1957-200941
- Grimke family papers, 1678-197736
- Allston Family Papers, 1730-190135
- Rabbi Jacob S. Raisin Papers33
- Millicent E. Brown Papers, 1949 - 200331