- Bowman Family Papers, 1835-18924
- Chesnut Family Papers, 1741-19004
- Cote Bas and Mepkin Plantations Journals, 1865-18774
- Hasell Family Papers, 1803 - 18844
- Henry Laurens papers, 1747-18604
- Mulberry Plantation Journals, 1853-1908 (bulk 1853-1889)4
- Pringle-Garden Family Papers, 1701-18824
- American Federation of Musicians Local 502 records, 1911-19143
- Horlbeck Brothers Records, 1824-18603
- John P. Berry Papers, 1844-18973
- Rose Hill Plantation Time Books, 18783
- Sandy Island Plantation Journals/Almanacs, 1792-17983
- Vanderhorst Family Papers, 1689-19423
- Account Books of Benjamin Perry’s Wards, 1841-18642
- Alexander Inglis Papers, 1782-1811 (bulk 1800-1802)2
- Charleston Iron Works records, 19072
- Cora Godfrey Justice Family Papers, 1816-19872
- Deas Family Papers and Research, 1766-19762
- Elizabeth W. Allston Pringle Family Papers, 1861-19262
- Emily Clarkson Ball Grainger Family Papers, 1839-1962 (bulk 1926-1950)2