- Lazarus and Hirsch Family Papers44
- Moses Family Papers44
- Walter Pantovic Slavery and African American History Collection43
- Thomas J. Tobias papers, ca. 1790-197042
- Hunley Artifact Collection – Personal Artifacts40
- Drayton Family Papers, 1837-186939
- Eola Willis Cuban photograph collection, circa 1895-191036
- Slave Records in the Discrete Manuscript Collection33
- Historical and Governing Records, 1841-192529
- Illustrated Newspaper Clippings, 1840-191729
- Kahal Kadosh Beth Elohim Congregation Records27
- Buildings and Properties, 1841-193726
- John McCrady Plats and Deeds Collection25
- Hampstead and Bethany Cemeteries24
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- Pearlstine-Strauss Family Papers24
- Cohen, Emanuel, Moses, Seixas Family Papers22
- Grimke family papers, 1678-197722
- Beaufort Hurricane of 1893 Photograph Collection20
- City Year Books for Charleston, South Carolina, 1880-195118