- Temple Sinai (Sumter, S.C.) Records106
- Halley's Comet Project, 1985-198688
- William Henry Jackson Photochrom Collection, 1898-190582
- Lawrence Layden Scrapbook, 1941-194581
- Lazarus and Hirsch Family Papers65
- L. Mendel Rivers Papers, 1940-196264
- Thomas J. Tobias papers, ca. 1790-197064
- City Year Books for Charleston, South Carolina, 1880-195162
- Harby, Moise, Levy, Moses, Davis Family Photographs55
- South Carolina LGBTQ Oral Histories, Archives, and Outreach54
- College of Charleston Board of Trustees Minutes52
- College of Charleston Magazines48
- Moses Family Papers46
- Illustrated Newspaper Clippings, 1840-191741
- Kahal Kadosh Beth Elohim Congregation Records39
- Eola Willis Cuban photograph collection, circa 1895-191036
- Irish Heritage Oral History Collection32
- Mitchell King Atlas, 1662-169531
- Harry Blas and Erika Stockfleth Blas Papers, circa 1910-circa 198025
- Zionist Organization of America Records25