- Pearlstine-Strauss Family Papers30
- Edmondston-Alston Photograph Collection28
- Ethelyn Murray Parker Papers27
- Flagg Family Papers, 1832-192625
- Images from the Records of the Charleston County Public Library24
- Miriam DeCosta Seabrook and Herbert U. Seabrook Papers, 1882-199521
- Charleston Naval Shipyard Photographs20
- Aqui Estamos19
- Slave Records in the Discrete Manuscript Collection18
- Edmondston-Alston Family Letters and Paper Materials, 1782-191917
- Heyward and Ferguson Family Papers, 1806-192316
- St. Andrew's Society of Charleston Records, 1729-200116
- Pierrine Smith Byrd Papers, 1919-199115
- Town of Sullivan's Island Historic Meeting Minutes15
- Harry Blas and Erika Stockfleth Blas Papers, circa 1910-circa 198014
- Pinehurst Tea Plantation Visual Materials14
- Charleston Museum Illustrated Newspapers Collection13
- Erastus W. Everson Papers, 1837-189313
- Drayton Family Papers, 1837-186910
- Langdon Cheves Papers, 1777-186410