- Hutson Lee Papers, 1858-186515
- Samuel Badger Papers, 1767-177314
- American Revolution Records in the Discrete Manuscript Collection13
- Adger Family Papers, 1813-193211
- James Simons Papers, 1832-187911
- Letters to Alfred Wardlaw, 1857-186211
- South Carolina Historical Society Oral Histories11
- Voices of the Santee Delta Oral History Project11
- Woodward Manning Papers, 1771-190611
- Ragsdale Family Papers, 1844-ca.192010
- South Carolina Historical Society Manuscripts10
- Glover Family Papers, 1729-ca.19559
- Ravenel Family Papers, 1695-19258
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558
- Records of the Church of the Holy Cross, 1788-19428
- Daily reports, 1863 Dec. 17-237
- Records of Charleston fire companies, 1862-18647
- Accounts and Estate Administration Books, 1824-18525
- Coffin Point Plantation Journals, 1800-18165
- R.P. Hamer business letters, 18875