- Esau Jenkins Papers, 1963-200399
- The Charleston Oral History Program86
- Charleston Museum Illustrated Newspapers Collection85
- Mamie E. Garvin Fields Papers, 1894 - 198782
- Agricultural Society of South Carolina Visual Materials77
- Isaiah Bennett Papers, ca. 1932-200271
- Ansonborough Rehabilitation Project70
- Leah Greenberg Postcard Collection70
- Ball Family Papers, 1631-189562
- Hampstead and Bethany Cemeteries58
- Buildings and Properties, 1841-193749
- College of Charleston Magazines48
- Grimke family papers, 1678-197746
- Historical and Governing Records, 1841-192541
- Book Lovers' Club, 1927 - 196939
- Kahal Kadosh Beth Elohim Congregation Records39
- Thomas J. Tobias papers, ca. 1790-197039
- City Year Books for Charleston, South Carolina, 1880-195136
- George W. Williams Photograph Collection25
- Helen Evangeline Banks Harrison papers (circa 1850 - 1985)21