- Charles Henry Meltzer Papers, 1839-19403
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995402
- Charleston Museum Illustrated Newspapers Collection13
- Charleston Museum Plantation Photographs1
- Charleston Naval Shipyard Photographs20
- Charleston Slave Passes1
- Church Session Books Excerpts, 1816-1901.1
- City Engineers's Plat Book, 1671-19517
- City of Charleston Board of Architectural Review Photographs Collection92
- Civic Services Committee Papers255
- Cleveland L. Sellers, Jr. Papers, 1934 - 2003183
- College of Charleston Buildings and Grounds Photograph Collection693
- College of Charleston Oral Histories7
- Colleton County Memorial Library Bookmobile History6
- Craft and Crum Families, 1780-20073
- Cranston Family Papers, 1822-19591
- Deas Family Papers and Research, 1766-19761
- Dientje Krant Kalisky Adkins Photographs, 1938-19961
- Drayton Family Papers, 1837-186910
- Drayton Papers, 1701-20043