- Slave Records in the Discrete Manuscript Collection86
- Flagg Family Papers, 1832-192674
- Charleston Museum Collection of Revolutionary War Letters70
- Cleveland L. Sellers, Jr. Papers, 1934 - 200366
- Drayton Family Papers, 1837-186965
- Isaiah Bennett Papers, ca. 1932-200257
- College of Charleston Board of Trustees Minutes52
- Thomas Pinckney papers, ca. 1790-ca. 1825.52
- College of Charleston Magazines48
- Thomas J. Tobias papers, ca. 1790-197045
- Gooch Family Papers, 1754-194744
- Walter Pantovic Slavery and African American History Collection44
- Ball Family Papers, 1631-189637
- Kahal Kadosh Beth Elohim Congregation Records33
- Mamie E. Garvin Fields Papers, 1894 - 198730
- Laura Bragg Papers28
- Eugene C. Hunt Papers, 1834 - 199425
- John C. Calhoun Letters, 1824-185025
- Zionist Organization of America Records25
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24